TOXICITY STUDIES ON VANGA BHASMA (Part I – with special reference to G. I. T. Liver and Pancreas)

Vangabhasma is a popular and effective dosage form prepared from tin metal in Ayurvedic practice. Since modern literature attributes certain toxicity to tin salts, an attempt is made to screen the acute and sub-acute toxicity of Vangabhasma in the form, dose and route as is in the practice or Ayurveda. In this paper, dose-effect relation of Vangabhasma on Digestive system (G.I. T., Liver and Pancreas) has been presented. But for local irritation, no significant toxicity attributable to Vangabhasma has been observed even in eight times higher dose than therapeutic dose, on exposure to the drug for ten days.